Choose a Store

Santa cruz biotechnology
Santa Cruz Animal Health

Choose a Language

English

     Français

     日本語

     中文

     한글

     Español

     Italiano

     Deutsch

     Svenska

     Português

Choose a Currency

     US Dollars

     Euro

     Swiss Francs

British Pounds

     Australian Dollars

     Canadian Dollars

     RMB

Santa cruz biotechnology
Santa Cruz Animal Health

  • Call toll free
    1-800-457-3801
  • Live chat
    Contact Us
  • Sign in/Sign up
    Account
    • Don’t have an account?

  • Quick
    Order
  • 0 cart
    Items

    • 0 Items in your shopping cart


  • Toll free  1-800-457-3801
  • Live chat
  • Sign in/Sign up
  • 0 ITEMS IN CART

    • 0 Items in your shopping cart

  • All
  • Antibodies
  • Support Products
  • Gene Editing
  • Chemicals
  • Lab Supplies


  • English
  •      Français
  •      日本語
  •      中文
  •      한글
  •      Español
  •      Italiano
  •      Deutsch
  •      Svenska
  •      Português

  •      US Dollars
  •      Euro
  •      Swiss Francs

  • British Pounds
  •      Australian Dollars
  •      Canadian Dollars
  •      RMB

FOLLOW US

FOLLOW US

Bleomycin Sulfate
A glycopeptide antibiotic

  1. Home
  2. Chemicals
  3. Carbohydrates and Lipids
  4. Glycosides
  5. Bleomycin Sulfate
Bleomycin Sulfate: sc-200134...

Click on image or enlarge button to enlarge
Bleomycin Sulfate: sc-200134...



Close

Bleomycin Sulfate (CAS 9041-93-4)

Bleomycin Sulfate | CAS 9041-93-4 is rated
5.0 out of
5 by
3.
  • y_2018, m_12, d_2, h_22
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.9
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_3
  • loc_en_US, sid_200134, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 6ms
  • REVIEWS, PRODUCT


See product citations (13)

Synonym:
Blenoxane
Application:
A glycopeptide antibiotic
CAS Number:
9041-93-4
Purity:
≥90%
Molecular Weight:
1512
Molecular Formula:
C55H84N17O21S3•H2SO4

* Refer to Certificate of Analysis for lot specific data (including water content).

Submit a review for this product and receive 15 CruzCredits

QUICK LINKS

  • Ordering Information
  • Description
  • Technical Information
  • Safety Information
  • Citations
  • SDS & Certificate of Analysis

  • Description

  • Technical Information

  • Safety Information

  • SDS & Certificate of Analysis

Bleomycin sulfate is the sulfate salt of a complex natural product antibiotic. This compound approximates metals such as Fe(II) which then coordinate dioxygen to generate the active species. This Bleomycin-metal-dioxygen species is capable of inducing oxidative cleavage of the DNA backbone, leading to apoptosis. The species also degrades RNA, and has been reported to display selectivity for RNA over DNA.

References

1. Petering, D.H., et al. 1990. Chem. Biol. Interact. 73: 133-182. PMID: 1690086
2. Hüttenhofer, A., et al. 1992. J. Biol. Chem. 267: 24471-24475. PMID: 1280260
3. Holmes, C.E., et al. 1997. Bioorg. Med. Chem. 5: 1235-1248. PMID: 9222517

Appearance
:
Powder

Physical State
:
Solid

Derived From
:
Streptomyces sp. MST-AS4458

Solubility
:
Soluble in water (20 mg/ml), methanol, moderate ethanol , PBS (pH 7.2) (10 mg/ml), DMF (2 mg/ml), and DMSO (13 mg/ml).

Storage
:
Store at -20° C

Melting Point
:
200-204° C (dec.)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany
:
3

RTECS
:
EC5991990

PubChem CID
:
131664136

Merck Index
:
14: 1318

MDL Number
:
MFCD00070310

EC Number
:
232-925-2

SMILES
:
CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=N)[O-])O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Bleomycin Sulfate 
Product Citations

See how others have used Bleomycin Sulfate. Click on the entry to view the PubMed entry
.

Citations 1 to 10 of 13 total

  • <
  • 1
  • &gt

PMID: # 28265008   Liu, CW. et al. 2017. Mol. Cancer Ther. 16: 1421-1434.

PMID: # 27869163   Schrock, MS. et al. 2016. Oncogene.

PMID: # 25837271   2015. Phytomedicine. 22: 344-51.

PMID: # 25483091   Cui, Y. et al. 2014. Cell cycle (Georgetown, Tex.). 13: 3541-50.

PMID: # 23485585   Myers, JM. et al. 2013. Free Radic. Biol. Med. 60: 183-94.

PMID: # 18245174   Yu, H. et al. 2008. FASEB J. 22: 1778-1789.

PMID: # 16251407   Walters, DM. et al. 2005. Am. J. Pathol. 167: 1221-1229.

PMID: # 12754187   Marshall, RP. et al. 2004. Am. J. Physiol. Lung Cell Mol. Physiol. 286: L156-L164.

PMID: # 10637286   Baber-Furnari, BA. et al. 2000. Mol. Biol. Cell. 11: 1-1-1111.

PMID: # 10734156   Gurujeyalakshmi, G. et al. 2000. J. Pharmacol. Exp. Ther. 293: 82-90.

Citations 1 to 10 of 13 total

  • <
  • 1
  • &gt

We failed to find to correct dose of Bleomycin Sulphate for the murine model of bleomycin-induced lung fibrosis. What do you advice? How to calulate the doses in Units, International Units and mg? Could you help us?
thanks

Asked by: mc5821
Thank you for the question. You might want to consult PubMed ID# 18245174 or the other currently listed 11 references we list for this compound.

Answered by: Technical Support Europe
Date published: 2018-01-09

After resuspension, what is the ideal storage temperature for the bleomycin sulfate solution?

Asked by: gargamel
Thank you for your question. We recommend to only prepare as much solution as you need at once time and to prepare fresh solutions for future use.

Answered by: Technical Support
Date published: 2017-11-08

Is it medical grade?

Asked by: chemsd02
Thank you for your question. sc-200134 (Bleomycin Sulfate, CAS 9041-93-4) is not offered in medical grade.

Answered by: Chemical Support 10
Date published: 2017-04-06

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-200134, is provided as a white to light yellow powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.

Answered by: Tech Service 8
Date published: 2017-07-20

Is this substance pharmaceutical grade and what’s the purity of this compound?

Asked by: Nupur

  • y_2018, m_12, d_5, h_1CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.9
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_5
  • loc_en_US, sid_200134, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 43ms
  • QUESTIONS, PRODUCT


Rated 5 out of
5
by
from
PMID 25837271 USED sc-200134
PMID 25837271 USED THIS PRODUCT. IT IS A VERY GOOD PRODUCT.

Date published: 2017-05-23



Rated 5 out of
5
by
from
A VERY GOOD PRODUCT
I USED IT IN MY MANUSCRIPT. IT IS A VERY GOOD PRODUCT.

Date published: 2017-04-04



Rated 5 out of
5
by
from
Yu
Yu, et. al. (PubMed ID 18245174) used bleomycin to induce lung fibrosis in mice. Also used to test whether Tagln expression would be augmented in ATII cells when treated with this antibiotic. -SCBT Publication Review

Date published: 2015-01-18

  • y_2018, m_12, d_2, h_22
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.9
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_3
  • loc_en_US, sid_200134, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 5ms
  • REVIEWS, PRODUCT

–%>

SIGN UP TODAY for News & Announcements

FOLLOW US

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2018 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.

Please login to your account



The email address or password you have entered is incorrect.
Hide



The email address or password you have entered is incorrect.
Hide

*
Required fields

SIGN IN WITH SOCIAL ACCOUNT

Please sign in using your account on one of the following social networks.

* loginWidget *

Welcome back, * welcomeName *!

* loginWidget *

Use another account

Your account has been deactivated.

Email address is required. Please provide a valid email address.

* #socialRegistrationForm *
* emailAddress *
* firstName *
* lastName *

* backButton *

* /socialRegistrationForm *

* mergeAccounts “custom”: true *


current_emailAddress

foundExistingAccountText .

moreInfoHoverText

rendered_existing_provider_photo

Created existing_createdDate at

Connect with your account?

* backButton *

Don’t have an account? Create a new account

Your email subscription to News & Announcements has been received. By signing up, you indicate that you have read and agree to the terms in our privacy policy . You have the right to unsubscribe at any time by clicking the ‘unsubscribe’ link in any News & Announcement emails you receive.

To place an order using RMB or to ship to mainland China, please visit www.scbio.cn



Create a new account



Email address already exists, please enter a new valid email address.
Hide

*
Required fields

USE YOUR SOCIAL NETWORK

Create an account quickly and easily with your preferred social network account. You won’t have to remember an extra name and password.

* loginWidget *

Welcome back, * welcomeName *!

* loginWidget *

Use another account

Why create an account?

Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.

Already have an account?